A New Humanized Mouse Model for Studying Inherited Cardiomyopathic Mutations in the MYH7 Gene
نویسندگان
چکیده
منابع مشابه
Mutations in the sarcomere gene MYH7 in Ebstein anomaly.
BACKGROUND Ebstein anomaly is a rare congenital heart malformation characterized by adherence of the septal and posterior leaflets of the tricuspid valve to the underlying myocardium. An association between Ebstein anomaly with left ventricular noncompaction (LVNC) and mutations in MYH7 encoding β-myosin heavy chain has been shown; in this report, we have screened for MYH7 mutations in a cohort...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.1434